Transmission from macaques to humans in public settings, such as parks, has not been documented. Nearly all documented B virus infections in humans involved exposures in laboratories or animal facilities ( 4). Hilliard, NBVRC, personal communication, 2019).
Seroconversion in some persons suggests that asymptomatic infection can occur (Julia K. Symptomatic B virus infection in humans is rare. Because B virus can establish a lifelong latent infection with possible subsequent illness ( 3), the patient was advised always to carry a Medical Alert card ** in case symptoms occur despite her initial negative tests ( 4). B virus can migrate to the dorsal ganglion and cause infection years later (Julia Hilliard, NBVRC, personal communication, 2019). ¶ Neither specimen was positive for antibodies against B virus.įollowing an initial exposure to B virus, the peripheral viral load can be insufficient to stimulate an immune response and can result in negative tests for antibodies against B virus. Per recommendations for persons possibly exposed to B virus, serum specimens were collected at that visit and 3 weeks later § (January 29) for B virus immunoglobulin (Ig) M and IgG testing at NBVRC. On January 8, 2019, the patient received the final dose of rabies vaccine. OPHD recommended that if illness compatible with B virus infection developed (e.g., fever, chills, myalgia, headache, blisters or discomfort near the wound, or problems with coordination) the patient should seek medical evaluation, and the provider should notify NBVRC immediately. OPHD contacted CDC, and the National B Virus Resource Center (NBVRC) in Atlanta, Georgia, to discuss testing. The case fatality rate of untreated B virus infection approaches 80% ( 2). This virus, commonly found in macaques, * can, in rare cases, cause severe encephalitic infection in humans if not treated promptly ( 1). Upon learning about the macaque bite, the local health department contacted OPHD, where staff members expressed concern about possible exposure to Macacine herpesvirus 1 (B virus). The physician contacted the local health department, seeking guidance about when to administer the final dose of rabies vaccine. On January 5, 2019, the patient left Thailand and was evaluated by a physician in Oregon on January 7. Photo/patientThe figure consists of two photos one shows the macaque biting the Oregon teen on the leg, and the second shows the resultant wound. Macaque monkey biting an Oregon resident in a public park in Thailand and the resultant wound - 2018
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